Publications

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2017

  • Urdaneta, M, AS Koivuniemi, KJ Otto. Central nervous system microstimulation: Towards selective micro-neuromodulation Current Opinion in Biomedical Engineering. 2017. [PDF]
  • Lee, HC, J Gaire, S Currlin, M McDermott, K Park, KJ Otto. Foreign Body Response to Intracortical Microelectrodes Is Not Altered with Dip-Coating of Polyethylene Glycol (PEG) Frontiers in Neuroscience. 2017. [PDF]
  • Spearman, B, V Desai, S Mobini, M Mc.Dermott, J Graham, KJ Otto, J Judy, C Schmidt. Tissue-Engineered Peripheral Nerve Interfaces Advanced Functional Materials. 2017.[PDF]
  • Nunamaker, E, B Spearman, J Graham, E Atkinson, V Desai, C Shafor, S Natt, R Wachs, C Schmidt, J Judy, K Otto. Implantation methodology development for tissue-engineered-electronic-neural-interface (TEENI) devices IEEE EMBS Conference. 2017.[PDF]
  • Desai, V, B Spearman, C Shafor, S Natt, B Teem, J Graham, E Atkinson, R Wachs, E Nunamaker, KJ Otto, C Schmidt, J Judy. Design, fabrication, and characterization of a scalable tissue-engineered-electronic-nerve-interface (TEENI) device IEEE EMBS Conference. 2017.[PDF]
  • Graham, J, E Atkinson, E Nunamaker, B Spearman, V Desai, C Shafor, S Natt, R Wachs, C Schmidt, J Judy, KJ Otto. Histological evluation of chronically implanted tissue-engineered-electronic-neural-interface (TEENI) devices IEEE EMBS Conference. 2017.[PDF]
  • Lee, HC, F Ejserholm, J Gaire, S Currlin, J Schouenborg, L Wallman, M Bengtsson, K Park, KJ Otto. Histological evaluation of flexible neural implants; flexibility limit for reducing the tissue response? Journal of Neural Engineering. 14(3). 2017.[PDF]
  • McDermott, M, KP Olczak, KJ Otto. Electrical Analysis of Minocycline Eluting Layer-By-Layer Thin-Films from Functional Micro-Electrode Arrays 8th International IEEE EMBS Conference on Neural Engineering. 2017. [PDF]
  • Lee, HC, J Gaire, B Roysam, KJ Otto. Placing sites on the edge of a planar silicon microelectrode enhances chronic recording functionality IEEE Transactions on Biomedical Engineering. 2017.[PDF]

2016

  • McDermott, M, KJ Otto. The effect of multiple thin-film coatings of protein loaded sol-gel on total multi-electrode array thickness. 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). pp. 129-132. 2016.[PDF]
  • Rossi, PJ, A Gunduz, J Judy, et al. The Third Annual Deep Brain Stimulation Think Tank: A Review of Emerging Issues and Technologies. Frontiers in Neuroprosthetics. 2016.[PDF]

2015

  • Rajan, AT, JL Boback, JF Dammann, FV Tenore, BA Wester, KJ Otto, RA Gaunt, SJ Bensmaia. The effects of chronic intracortical microstimulation on neural tissue and fine motor behavior. Journal of Neural Engineering. 12 (6), 066018. 2015.[PDF]
  • Vedam-Mai, V, AT Yachnis, KJ Otto, A Gunduz, AW Shukla, C Hess, MS Okun. Histopathological observations from 50 human deep brain stimulation cases. Movement Disorders. Vol. 30. pp. S292. 2015.
  • McDermott MD, J Zhang, KJ Otto. Improving the brain machine interface via multiple Tetramethyl Orthosilicate sol-gel coatings on microelectrode arrays. Proceedings of the 7th International IEEE/EMBS Conference on Neural Engineering. 2015.[PDF]
  • Ward, M, K Otto, K Qing, R Worth, S John, and P Irazoqui. A flexible platform for biofeedback-driven control and personalization of electrical nerve stimulation therapy. IEEE Transactions on Neural Systems and Rehabilitation Engineering PP(99):1-1. 2015.[PDF]
  • Wodicka, JR, NI Onunkwo, AJ Woolley, A Panitch, and KJ Otto. A cell-penetrating peptide for inhibiting MAPKAP Kinase 2-mediated inflammatory cytokine release following glial cell activation. World Journal of Neuroscience 5 (02), 115. 2015. [PDF]

2014

  • Sommakia, S, JL Rickus, and KJ Otto. Glial cells, but not neurons, exhibit a controllable response to a localized inflammatory microenvironment in vitro. Frontiers in Neuroengineering. 14;7:41. doi: 10.3389/fneng.2014.00041. 2014. [PDF]
  • Dale, J, J Gaire, KJ Otto. Quantification of LPS Eluate from Coated Microelectrode Devices. [PDF]
  • Harden, MA, MD McDermott, KJ Otto. Thin-Film Sol-Gel as Controlled Delivery Platform for Neural Microelectrodes. [PDF]
  • Koivuniemi, AS and KJ Otto. When “Altering Brain Function” becomes “Mind Control”. Frontiers in Systems Neuroscience. 14;8:202. doi: 10.3389/fnsys.2014.00202. 2014. [PDF]
  • Sommakia, S, HC Lee, J Gaire, and KJ Otto. Materials approaches for modulating neural tissue responses to implanted microelectrodes through mechanical and bioc hemical means. Current Opinion in Solid State & Materials Science. 18 (6), 319-328, 2014. [PDF]
  • Lycke, R, A Schendel, JC Williams, and KJ Otto. In vivo evaluation of a μECoG array for chronic stimulation. Proceedings of the 36th Annual IEEE EMBS International Conference, 2014. [PDF]
  • Lee, HC, J Gaire, S McDowell, and KJ Otto. The effect of site placement within silicon microelectrodes on the long-term electrophysiological recordings. Proceedings of the 36th Annual IEEE EMBS International Conference, 2014. [PDF]
  • Sommakia, S, S Wyatt, KJ Otto, A Vadlamani, AL Garner. Nanosecond pulsed electric field interactions with microglia and astrocytes. 2014 IEEE International Power Modulator and High Voltage Conference, doi: 10.1109/IPMHVC.2014.7287296, 2014. [PDF]
  • Sommakia, S, J Gaire, JL Rickus, KJ Otto. Resistive and reactive changes to the impedance of intracortical microelectrodes can be mitigated with polyethylene glycol under acute in vitro and in vivo settings. Frontiers in Neuroengineering, doi: 10.3389/fneng.2014.00033, 2014. [PDF]
  • Ward, M, K Otto, K Qing, R Worth, S John, and P Irazoqui. A flexible platform for biofeedback-driven control and personalization of electrical nerve stimulation therapy. IEEE Transactions on Neural Systems and Rehabilitation Engineering, PP(99):1-1. 2014. [PDF]
  • Chen KH, JF Dammann, JL Boback, FV Tenore, KJ Otto, RA Gaunt, and SJ Bensmaia. The effect of chronic intracortical microstimulation on the electrode-tissue interface.Journal of Neural Engineering. 11 026004. doi:10.1088/1741-2560/11/2/026004. 2014. [PDF]

2013

  • Woolley, AJ, HA Desai, J Gaire, AL Ready, and KJ Otto. A systemic triple label strategy for fluorescent microscopy of inflammation in CNS and non-CNS tissue.Microscopy and Microanalysis. 19(S2):196-197. 2013. [PDF]
  • Regele, OB, AS Koivuniemi, KJ Otto. Constant RMS versus constant peak modulation for the perceptual equivalence of sinusoidal amplitude modulated signals.Proceedings of the 35th Annual IEEE EMBS International Conference. 3115-3118. 2013. [PDF]
  • Woolley, AJ, HA Desai, and KJ Otto. Chronic intracortical microelectrode arrays induce non-uniform, depth-related tissue responses.Journal of Neural Engineering. 10(2):026007. 2013. [PDF]
  • Ochoa, M, P Wei, AJ Woolley, KJ Otto, and B Ziaie. A hybrid PDMS-Parylene subdural multi-electrode array.Biomedical Microdevices, DOI 10.1007/s10544-013-9743-2. 2013. [PDF]
  • Woolley, AJ, HA Desai, J Gaire, AL Ready, and KJ Otto. Intact histological characterization of brain-implanted microdevices and surrounding tissue.Journal of Visualized Experiments, (72), e50126, doi:10.3791/50126. 2013. [Video]
  • Nunamaker, EA, KJ Otto, JE Artwohl, and JD Fortman. Leaching of heavy metals from water bottle components into the drinking water of rodents.Journal of the American Association for Laboratory Animal Science, 52(1):22-27. 2013. [PDF]

2012

  • Sundararajan, R, F Xiao, T Salameh, LM Reece, L Campana, IG Camarillo, JF Leary, and KJ Otto. Effective proliferation control of human cancer cells using electrical pulses.IEEE Transactions on Dielectrics and Electrical Insulation. 19(6):2225-2236. 2012. [PDF]
  • Koivuniemi, AS and KJ Otto. The depth, waveform, and pulse rate for electrical microstimulation of the auditory cortex.Proceedings of the 34th Annual IEEE EMBS International Conference, 2489-92. 2012. [PDF]
  • Sundararajan, R, F Xiao, KJ Otto, and IG Camarillo. The dielectric properties of electroporated human breast cancer cells.2012 IEEE 10th International Conference on the Properties and Applications of Dielectric Materials (ICPADM). 2012.[PDF]
  • Otto, KJ and JC Williams. Novel In Vitro and In Vivo Neural Interfaces.IEEE Pulse. 2012. [PDF]
  • Wilks, SJ, TJ Richner, JC Williams, and KJ Otto. Voltage Biasing, Cyclic Voltammetry, & Electrical Impedance Spectroscopy for Neural Interfaces.Journal of Visualized Experiments. 2012. [Video]

2011

  • Koivuniemi, AS, OB Regele, JH Brenner, and KJ Otto. Rat Behavioral Model for High-Throughput Parametric Studies of Intracortical Microstimulation.Proceedings of the 33rd Annual IEEE EMBC International Conference. 2011. [PDF]
  • Wilks, SJ, AJ Woolley, L Ouyang, DC Martin, and KJ Otto. In Vivo Polymerization of Poly(3,4-ethylenedioxythiophene) (PEDOT) in Rodent Cerebral Cortex.Proceedings of the 33rd Annual IEEE EMBC International Conference. 2011. [PDF]
  • Koivuniemi, AS, and KJ Otto. Asymmetric Versus Symmetric Pulses for Cortical Microstimulation.IEEE Transactions in Neural Systems and Rehabilitation, 19(5):468-476. 2011. [PDF]
  • Koivuniemi, AS, SJ Wilks, AJ Woolley, and KJ Otto. Multimodal, longitudinal assessment of intracortical microstimualtion.Progress in Brain Research, 194:131-144. 2011. [PDF]
  • Lempka, S, MD Johnson, M Moffitt, KJ Otto, DR Kipke, and C McIntyre. Theoretical Analysis of Intracortical Microelectrode Recordings.Journal of Neural Engineering, 8 045006. 2011. [PDF]
  • Woolley, AJ, H Desai, MA Steckbeck, N Patel, and KJ Otto. In situ characterization of the brain-microdevice interface using Device Capture Histology.Journal of Neuroscience Methods 201:67-77. 2011. [PDF]
  • McCarthy, PT, MP Rao, and KJ Otto. Simultaneous recording of rat auditory cortex and thalamus via a titanium-based multi-channel, microelectrode device.Journal of Neural Engineering, 8 046007. 2011. [PDF]
  • McCarthy, PT, KJ Otto, and MP Rao. Robust penetrating microelectrodes for neural interfaces realized by titanium micromachining.Biomedical Microdevices, DOI 10.1007/s10544-011-9519-5. 2011. [PDF]

2010

  • Nunamaker, EA, KJ Otto, and DR Kipke. Investigation of the material properties of alginate for the development of hydrogel repair of dura mater.Journal of the Mechanical Behavior of Biomedical Materials, 4(1):16-33. 2010. [PDF]

2009

  • Xiao, F, KJ Otto, I Camarillo, R Sundararajan. Impedance spectroscopy studies of electroporated human breast cancer cells. Proceedings of the CEIDP ’09. IEEE Conference on Electrical Insulation and Dielectric Phenomena, 470-3. 2009. [PDF]
  • McCarthy, PT, R Madangopal, KJ Otto, and MP Rao. Titanium-based multi-channel, micro-electrode array for recording neural signals.Proceedings of the 31st Annual IEEE EMBC International Conference, 2062-5. 2009. [PDF]
  • Sommakia, SS, Rickus, JL, and KJ Otto. Effects of adsorbed proteins and an antifouling agent and long-duration DC voltage pulses on the impedance of silicon-based neural microelectrodes.Proceedings of the 31st Annual IEEE EMBC International Conference, 7139-42. 2009. [PDF]
  • Wilks, SJ, AS Koivuniemi, S Thongpang, JC Williams, and KJ Otto. Evaluation of micro-electrocorticographic electrodes for electrostimulation.Proceedings of the 31st Annual IEEE EMBC International Conference, 5510-3. 2009. [PDF]
  • Wilks, SJ, SM Richardson-Burns, JL Hendricks, DC Martin, and KJ Otto. Poly(3,4-ethylene dioxythiophene) (PEDOT) as a micro-neural interface material for electrostimulation.Frontiers in Neuroengineering, 2:7. Doi:10.3389/neuro.16.007.2009. 2009. [PDF]
  • Pierce, AL, S Sommakia, RL Rickus, and KJ Otto. Thin Film Silica Sol-Gel Coatings for Neural Microelectrodes.Journal of Neuroscience Methods, 180:106-110. 2009. [PDF]

2008

  • Elman A, E Bartlett, N Kong, and KJ Otto. Analysis of Sensory Transformations in Response to Complex Sensory Stimuli in the Auditory Pathway.Proceedings of the 3rd INFORMS Workshop on Data Mining and Health Informatics, DM-HI. 2008. [PDF]
  • Sundararajan, R, D Campbell, J Harper, F Xiao, R Ma, and KJ Otto. Characterization of fruit juices treated with electrical pulses.Annual Report of the IEEE Conference on Electrical Insulation & Dielectric Phenomena. 26-29 Oct., 1:536-539. 2008. [PDF]

2006

  • Otto, KJ, MD Johnson, and DR Kipke. Voltage Pulses Change Neural Interface Properties and Improve Unit Recordings with Chronically Implanted Microelectrodes.IEEE Transactions on Biomedical Engineering, 53(2):333-40. 2006. [PDF]
  • Lempka, SF, MD Johnson, DW Barnett, MA Moffitt, KJ Otto, DR Kipke and CC McIntyre. Optimization of microelectrode design for cortical recording based on thermal noise considerations.Proceedings of the 28th Annual IEEE EMBC International Conference, 1:3361-3364. 2006. [PDF]

2005

  • Otto, KJ, PJ Rousche, and DR Kipke. Microstimulation in Auditory Cortex Provides a Substrate for Detailed Behaviors.Hearing Research, 210(1-2):112-117. 2005. [PDF]
  • Otto, KJ, PJ Rousche, and DR Kipke. Cortical microstimulation in auditory cortex of rat elicits best-frequency dependent behaviors.Journal of Neural Engineering, 2:42-51. 2005. [PDF]
  • Johnson, MD, KJ Otto, and DR Kipke, Repeated voltage biasing improves unit recordings by reducing resistive tissue impedances, (Invited), IEEE Transactions on Neural Systems and Rehabilitation Engineering, 13(2):160-165. 2005. [PDF]
  • Gage, GJ, KA Ludwig, KJ Otto, EL Ionides, DR Kipke, Naïve coadaptive cortical control,Journal of Neural Engineering, 2:52-63. 2005. [PDF]

2004

  • Johnson MD, KJ Otto, JC Williams, and DR Kipke. Bias voltages at microelectrodes change neural interface properties in vivo.Proceedings of the 26th Annual IEEE EMBS International Conference. 6:4103-4106. 2004. [PDF]
  • Ghovanloo M, KJ Otto, DR Kipke, and K Najafi. In vitro and in vivo testing of a wireless multichannel stimulating telemetry microsystem.Proceedings of the 26th Annual IEEE EMBS International Conference. 6:4294-4297. 2004. [PDF]
  • Gage GJ, KJ Otto, KA Ludwig, and DR Kipke. Co-adaptive Kalman filtering in a naive rat cortical control task.Proceedings of the 26th Annual IEEE EMBS International Conference. 6:4367-4370. 2004. [PDF]

2003

  • Otto, KJ, PJ Rousche, and DR Kipke. The benefits of modular brain-machine interface system design.Proceedings of the 25th Annual IEEE EMBS International Conference. 3: 2208-2211. 2003. [PDF]
  • Otto, KJ, RJ Vetter, TC Marzullo, and DR Kipke. Brain-machine interfaces in rat motor cortex: implication of adaptive decoding algorithms.Proceedings of the 1st International IEEE EMBS Conference on Neural Engineering. 1:100-103. 2003. [PDF]
  • Vetter, RJ, KJ Otto, TC Marzullo, and DR Kipke. Brain-machine interfaces in rat motor cortex: neuronal operant conditioning to perform a sensory detection task.Proceedings of the 1st International IEEE EMBS Conference on Neural Engineering. 1:637-640. 2003. [PDF]
  • Rousche, PJ, KJ Otto, and DR Kipke. Single electrode micro-stimulation of rat auditory cortex: an evaluation of behavioral performance.Hearing Research, 179(1-2): p. 62-71. 2003. [PDF]
  • Otto, KJ. Intracortical microstimulation for sensory inputs in brain-machine interfaces. Ph.D. Dissertation, Arizona State University, Tempe, AZ. [PDF]

1999

  • Witte, RS, KJ Otto, JC Williams, and DR Kipke. Pursuing dynamic reorganization in auditory cortex using chronic multichannel unit recordings in awake, behaving cats.Neurocomputing, 26-27:593-600. 1999. [PDF]
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